Development of Ketoconazole Shampoo with Dipterocarpus alatus Oil as a Permeation Enhancer
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چکیده
منابع مشابه
Oligostilbenoids with acetylcholinesterase inhibitory activity from Dipterocarpus alatus.
Phytochemical investigation of the stem wood of Dipterocarpus alatus led to the isolation and characterization of four new oligostilbenoids, dipterocarpols A-D (1-4), together with two known resveratrol oligomers, hopeahainol (5) and hopeafuran (6). The structures of the new compounds were determined by comprehensive spectral analysis including 1D and 2D NMR, and high-resolution MS. The absolut...
متن کاملKetoconazole shampoo: effect of long-term use in androgenic alopecia.
BACKGROUND The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. OBJECTIVE The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. METHOD T...
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A high performance liquid chromatography isocratic procedure was developed for the assay of ketoconazole in shampoo. Two solutions, (A) monoisopropylamine-methanol (2:500, v/v) and (B) ammonium acetate-water (1:200, w/v) were prepared. The mobile phase is a mixture of A and B (7:3, v/v), with pH adjusted to 5.5 with acetic acid. The chromatographic system consists of a LiChrospher® 100 RP-8 col...
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Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics model of drug diff...
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The authors have previously designed, developed, and characterized a novel microencapsulated formulation as a platform for the targeted delivery of therapeutics in an animal model of type 2 diabetes, using the drug probucol (PB). The aim of this study was to optimize PB microcapsules by incorporating the bile acid deoxycholic acid (DCA), which has good permeation-enhancing properties, and to ex...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Education and Research
سال: 2018
ISSN: 0019-5464
DOI: 10.5530/ijper.52.4s.98